报告题目：Exploring Cell Trafficking: Discovery and Applications
报告人：Francis Lin教授, 加拿大曼尼托巴大学（University of Manitoba）
Cell trafficking (i.e. the transport of biological cells in the body) is critically involved in many physiological processes ranging from immune responses to tissue development and to cancer metastasis. At the center of the cell trafficking process is cell migration directed by various environmental guiding factors such as chemical gradient, mechanical stimulation and electric field. The underlying mechanism of cell migration involves highly regulated biochemical and biophysical processes to enable effective “walking” and “running” of the cell. The migratory ability of cells together with the dynamic interaction between cells and their microenvironments orchestrate cell trafficking in tissues. Thus, a major research focus of my group at the University of Manitoba in Canada is on mechanistic studies of cell migration and trafficking using innovative microfluidic devices, quantitative modeling and modern approaches in biology and immunology. The accompanying emphasis of my research is on developing cell trafficking related biomedical applications. In this talk, I will start with a mini-tutorial on cell migration and trafficking and the relevant research methods to provide the background. Then I will introduce our work in combining experiments and modeling to understand T cell migration in secondary lymphoid tissues, and development of integrated microfluidic systems for cell migration and cell-cell interaction studies. Relevant biomedical applications will also be discussed. In addition, I will introduce our international collaborative research to study collective cell migration for wound healing by experimental and modeling approaches. I will conclude the talk by sharing my vision and plans for future studies.
Francis Lin obtained his B.S. in Applied Physics from Beijing University of Aeronautics and Astronautics (China) in 1998. This was followed by a M.S. in Physics from California State University-Fullerton in 2001. He received his Ph.D. in Physics in 2004 from the University of California-Irvine. From 2005 to 2008, he was a postdoctoral scholar at Stanford University School of Medicine. Francis joined the Department of Physics and Astronomy at the University of Manitoba in 2008 and is currently a tenured Associate Professor. His lab at the University of Manitoba studies environmental guiding mechanisms for the migration of different biological cells with the focus on chemical and electrical cues using a combination of microfluidic devices, quantitative modeling and cell biology and immunology approaches. In addition, his lab has been developing microfluidic tools for a range of biological and biomedical applications. Francis’ past and current research has been supported by training fellowships from NIH and grants from Stanford Bio-X, the University of Manitoba, and various Canadian funding agencies such as NSERC, CIHR, CFI and Research Manitoba. He has been on the executive team of the Division of Physics in Medicine and Biology for the Canadian Association of Physicists, and served as the division chair for 2018-2019.